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The pathway leading to the formation of GSH by the action of -glutamylcysteine synthetase (GCS) is blocked by buthionine sulfoximine (BSO), inducing artificial stress condition in dHL60 cells

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doi: 10.1038/nrrheum.2014.80 194 YuanKZhuQLuQJiangHZhuMLiXet al

Moreover, both (M+D)/2 and (M+D+V)/3 significantly decreased phosphorylation of RRM2 at Ser-80 and Ser-86 residues