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Site- and condition-specific imputation was performed using the scImpute function in PhosR (88) if the protein was quantified in more than 50% of samples from the same drug treatment

Recent evidence has shown that AKT1 actually phosphorylates tuberin at 4 sites (S939, S1130, S1132, T1462) all of which result in inhibition of the Rheb-GAP activity of the TSC1/TSC2 complex

This chapter provides details on the pathophysiology, prevalence, genetics and treatments for these adipofascial disorders along with recommendations for the care of people with these diseases

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