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Therefore, investigators are continuing to seek a better understanding of these antagonists using animal models [145] and continue to research alternatives for IGF-1 antagonists to improve targeted therapies [212]

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Subsequently, AA undergoes enzymatic conversion through two principal pathways: the cyclooxygenase (COX) pathway, which generates prostaglandins (PGs), and the lipoxygenase (LOX) pathway, which produces leukotrienes (LTs), lipoxins (LXs), and hydroxyeicosatetraenoic acids (HETEs) [160]