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2 = diffuse occurrence of 510 necrotic cells/HPF

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The antioxidant response signals induce the activation of nuclear factor erythroid-derived 2-like-2 (Nrf2)

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The amino acid deprivation, including Gln blockage, inhibits signaling mediated by mTORC1 as a nutrient sensor that could explain a synergistic effect of the therapies targeting Gln catabolism and inhibiting mTOR activity

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