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Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer

Mechanistically, this effect relies on direct interaction between VDR and the C-terminal domain of -catenin, which competitively disrupts -catenins formation of transcriptional complexes with T-cell factor (TCF), leading to suppression of Wnt/-catenin signaling activity [223, 224]

doi:10.1038/nrd1750 [PubMed] [Crosslink] 63

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