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The choice of SH-SY5Y cells was guided by their status as a permanently established neuronal cell line, valued for their human origin, possession of catecholaminergic neuronal properties, and ease of maintenance 38

Preclinical findings may suggest mechanisms worth studying, but limited human evidence cannot establish broad clinical effectiveness, optimal dosing, long-term safety, or superiority over standard care

Beyond butyrate: microbial fiber metabolism supporting colonic epithelial homeostasis

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Pancras, London.