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The mechanisms of hunger reduction in subjects treated with PYY is not clear but the finding of the reduction in plasma preprandial ghrelin concentration suggests that the interaction between these two gut peptides could contribute to the anorexigenic effect of PYY ( Fig

& Davies, M

Compared with GLP-1 RAs, more participants receiving tirzepatide 15 mg discontinued treatment due to adverse events (OR 2.29 [95% CI 1.39, 3.75], I 2 0%), whereas no difference was evident for tirzepatide 5 mg and 10 mg (ESM Table 3)

Cham: Springer International Publishing

N Engl J Med 377(3):300301

Omitted areas of research include, oleoylethanolamide (OEA), a fatty acid structurally related to endogenous cannabinoids, which has been found to reduce food intake and body weight (34) and is currently under active investigation and an antagonist of the CB 1 endocannibinoid receptor (Rimonabant