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10.1038/s41564-018-0307-3 415 SudoN.ChidaY.AibaY.SonodaJ.OyamaN.YuX.-N.et al

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One randomized placebo-controlled trial that assessed the effect of oral lipoic acid supplementation in 58 patients diagnosed with metabolic syndrome, a condition characterized by abnormal glucose and lipid metabolism, showed that flow-mediated vasodilation improved by 44% with 300 mg/day of lipoic acid for four weeks (66)