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Patients should also seek evaluation if they experience numbness, tingling, or color changes in fingers and toes (particularly white, blue, or red discoloration), which could indicate peripheral vascular issues or Raynaud's phenomenon rather than simple cold sensitivity

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Doses ranging from 0.3 to 10 mg were administered to healthy male subjects, resulting in a statistically significant erectile response at doses greater than 1.0 mg

This direct entry means the compound avoids enzymatic degradation in the gut and first-pass metabolism in the liver, both of which destroy the vast majority of peptide-based medications when swallowed

Wessells H, Fuciarelli K, Hansen J, et al

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