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The advisory committee focused on lab studies showing that MOTS-c has the potential to help treat obesity and osteoporosis, but there is very little evidence from human trials to support its safe, effective use

Diabetes Obes Metab 2025;27(7):3780-3788

10 In comparison of acute vs chronic impact of GLP-1 receptor agonists, a nationwide register-based study found a profound impact of GLP-1 receptor agonists on AUD as evaluated through alcohol-related and benzodiazepine withdrawal treatments in the initial 3 months when compared with DPP4 inhibitors

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There are also the side effects like nausea, vomiting and constipation associated with the buildup of food and waste in the digestive tract