ph of glutathione and endosomal pH-responsive hybrid vesicles fabricated by zwitterionic polymer block poly(l-aspartic acid) as a smart anticancer delivery platform 32 wnat will be the

doi: 10.1371/journal.pgen.1004488 11 Miljkovic-GacicIFerrellREPatrickALKammererCMBunkerCH

Radiotherapy has been widely used in tumors such as skin, cervical, head-and-neck, laryngeal, nasopharyngeal, prostate, and breast cancer, however, many types of tumors, including glioblastoma, soft-tissue cancers as well as non-small cell lung cancer are less sensitive to radiotherapy due to their intrinsic resistance

Fernandez-Rojo, M

With a 5-year overall survival of barely 510% and the highest incidence-to-mortality ratio of any solid tumor, PC has one of the highest mortality rates among cancers [68]

Supernatant was then transferred to a glass vial for LC-MS analysis

Meanwhile, GSH preservation in cytosolic and mitochondrial fractions downregulates the expression of RIPK1, RIPK3, or MLKL, preventing necrosome formation 74,75