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Kovacs E, Szabo K, Varvara R-A, Uiflean A, Cozma A, Vulturar R, et al

Metformin was also demonstrated to alter expression of genes involved in metabolism, specifically inhibition of oxidative phosphorylation genes, supporting functional analyses and highlighting metformin as a metabolic modulator in rectal cancer

If you suddenly stop urinating normally despite adequate fluid intake, it could indicate acute kidney injury

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The result is a sense of satiety, diminishing the desire to ingest more food, tobacco, alcohol, or maybe even recreational drugs