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Yes, IGF-1 LR3 operates through the IGF-1 receptor and PI3K/Akt/mTOR pathway, which is mechanistically distinct from androgen receptor (AR) signaling used by SARMs and anabolic steroids, meaning no direct receptor competition occurs and the pathways produce additive anabolic effects

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Oxidative Med Cell Longev 2016:9303606 Hasan H, Bhushan S, Fijak M, Meinhardt A (2022) Mechanism of inflammatory associated impairment of sperm function, spermatogenesis and steroidogenesis