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However, the further clinical development of pramlintide/metreleptin combination therapy has been discontinued by the manufacturing companies because of safety concerns [249](Table 3 )

doi: 10.1016/0035-9203(79)90128-7 157 ChippauxJP

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Inflammation Res (2008) 57(4):15762

Once bound, it activates the PI3K/Akt and mTOR pathways , which regulate: Protein synthesis (muscle building) Cell proliferation and differentiation Glycogen storage Fat metabolism In simpler terms: IGF-1 LR3 tells your muscles to grow , recover , and use nutrients more efficiently but it also stimulates cell growth everywhere, not just in muscles

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