The body is simultaneously adapting to metabolic changes from the medication
A better approach is to ask a different question: How do I help my body lose fat while keeping as much muscle, strength, and performance as possible
Cleveland Clinic explains that cutting calories too aggressively can lead to side effects like fatigue, headaches, dehydration, nausea and irritability, and that overly restrictive diets can also slow your metabolism. While losing weight on a calorie deficit, staying hydrated, and eating enough protein-rich foods can help you feel fuller and stay active. Do I need heavy weights to protect muscle on GLP-1 Not necessarily
Youll also visit a lab to have blood work drawn so the team can assess your baseline health
For full mechanistic detail and trial data, see the Retatrutide Research Guide
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