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Nonetheless, the mechanistic alignment between these pathways provides a biologically plausible rationale for future investigationparticularly in the context of dementia prevention, where upstream metabolic and vascular interventions may offer greater leverage than late-stage amyloid-targeted approaches

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For example, this commenter noted that the survey can ask patients about their experience with anesthesia or pain medications, including questions on numbness or increased pain, to provide actionable feedback and support follow-up care after outpatient procedures

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