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In addition to complex I deficiency, dysfunction of mitochondrial quality control pathwaysspecifically PINK1/Parkin-mediated mitophagyplays a pivotal role

Ann N Y Acad Sci 1258:2533

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While current experimental techniques have been unable to determine the most significant form of cell death in IRI-AKI or whether they interact with each other, studies using animal models have provided increasing amounts of evidence of a correlation between RCD and IRI-AKI