Glucagon receptor activation appears to affect reward circuitry associated with eating, not just satiety signals
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Additionally, semaglutide decreases the release of glycogen from the liver into the blood, which further pushes the reliance of the body onto the utilization of fatty acids for energy
Beyond weight management, Semaglutide has demonstrated cardiovascular risk reduction in patients with type 2 diabetes, making it an attractive option for individuals with obesity-related comorbidities
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Patients needing more aggressive weight reduction (20%+ body weight loss) are likely better served by tirzepatide or future triple-agonist therapies like retatrutide that produce higher average weight loss
