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Another study found that patients with type 2 diabetes and kidney disease who were prescribed GLP-1s had a 39% higher risk of requiring kidney replacement therapy (dialysis or transplant), compared to patients taking SGLT2 inhibitors

If there is significant hanging skin, especially after prior obesity or very large weight loss, non-surgical tightening may improve skin quality and modest laxity, but it cannot remove large amounts of extra skin

Some reports were higher still, with 27% of employers finding GLP-1 weight loss coverage encompassed more than 15% of their annual claims in 2024, compared to 15% of employers who said the same in 2023

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Because peptide drugs are difficult to absorb orally at reliable doses