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10.1101/2023.06.16.545386 bioRxiv

Factors that deplete glutathione include: Trauma Aging Medications Chronic stress Chemical pollutants Environmental Toxins Radiation Poor diet Considering the stressful, polluted world we live in, it is not surprising that many people become glutathione deficient

These enzymes orchestrate tryptophan catabolism, with tryptophan hydroxylase (TPH) catalyzing the conversion of tryptophan (Trp) to serotonin

27 , 10671080.e5 (2018)

B12 is not a thermogenic agent and does not suppress appetite in people who are not deficient