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It's important to note that tirzepatide carries a boxed warning for thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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Immediate, low-risk tactics can help, for example, a brisk 5 to 10-minute walk after meals, slow, deep chewing, or targeted OTC aids like simethicone or lactase for specific situations

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All of the conditions in blue below indicate signficant reductions in risk for those taking GLP-1 drugs compared to usual care (indicated by hazard ratios that are less than 1, so to the left of the dotted line)