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The parasympathetic afferent and efferent arms of the Vagus nerve (VN) serve as a control center that connects impulses between the brain and internal organs (2)

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5.2.4 Novel pharmacotherapies and combination treatment As a multifactorial degenerative disease, OA often responds poorly to single-target therapies ( Increasingly, ferroptosis is recognized as central to the multifaceted and dynamic pathophysiology of OA