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Consequently, these proteins mediate the expression of NF-B transcription factors and their proinflammatory effects [80,81,82,83,84]

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Zhang XL, Feng YL Zhou BA & Wei GY

Across the HF spectrum, their effects may differ according to phenotype, with potentially greater utility in patients with obesity or HFpEF, whereas their role in established HFrEF remains uncertain and should be individualized pending dedicated outcome trials [22]