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Daily intragastric administration of BBR (150 mg/kg, combined with 20 mg/kg Ginsenoside Rb1) to rats for four consecutive weeks significantly upregulates BDNF protein expression in the hippocampus (Zhang et al., 2021c)

10.1016/j.cmet.2015.02.005 [DOI] [PubMed] [Google Scholar] 98.Yusta B, Baggio LL, Koehler J, Holland D, Cao X, Pinnell LJ, et al

Major adverse limb events included any peripheral arterial disease, claudication, critical limb ischemia, endovascular therapy, peripheral bypass, and nontraumatic amputation

This modification enhanced the stability of GO adsorbent, which is improved by the 1-OA gelator that prevents aggregation

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These complications are uncommon and are more related to rapid weight loss, rather than the treatments themselves, but require immediate medical attention if symptoms persist