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Thermal damage extends beyond the visible wound, creating zones of injury with varying degrees of tissue viability

J Clin Biochem Nutr (2015) 56:17

This dual approach to sustainable and lifelong health is in line with contemporary views on human physiology and health (173175), which requires a systemic perspective that integrates multimodal data from various entities to create a network functioning in health and disease and to explore its dynamic responses to disturbances (176)

As previously noted, for joint symptoms at least, etanercept 50 mg twice weekly was no more effective than once weekly dosing in the PRESTA trial