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The potential downsides of peptide therapy include side effects like fatigue, joint stiffness, or water retention if dosing isnt customized properly

In the STEP-4 randomized trial (Rubino and colleagues, JAMA, 2021), the 803 adults who switched to placebo at week 20 regained about 6.9 percent of body weight over the next 48 weeks, while those who continued semaglutide kept losing

A major concern is the association with an increased incidence of autoimmune inflammation and related disorders, attributable to the ability of certain probiotic strains to overactivate immune responses

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However, in about 20% of patients, the shunt may narrow, causing varices to re-bleed at a later time