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Graphical Abstract 1 Introduction A century ago, Sugimura et al

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Tirzepatide has shown significant weight loss results in clinical trials

5-7 These findings have spurred interest among clinicians in the potential use of metformin for inflammatory conditions, including dermatologic diseases such as psoriasis and hidradenitis suppurativa (HS)

Among the identified compounds were two glutathione conjugate isomers, conjugates with cysteine, sulfate and oxidized glutathione and other biotransformation products such as phenylvaleric acid derivatives

It enhances neuronal survival, promotes angiogenesis and synaptic plasticity, and modulates key neurotransmitter systems, including dopaminergic, serotonergic, and GABAergic pathways