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According to FDA labeling, no dose adjustment is required for patients with renal impairment, including those with end-stage renal disease (ESRD)

The Phase 3 program includes trials in obesity, type 2 diabetes, and metabolic dysfunction-associated steatohepatitis (MASH, formerly known as NASH)

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Higher doses of tirzepatide helped patients with obesity lose roughly 20.9% of their body weight on average in late-stage studies, when analyzing all patients regardless of discontinuations

This form of magnesium also supports sleep quality and muscle recovery, providing benefits beyond constipation relief

All trials evaluate weekly subcutaneous retatrutide alongside healthy diet and physical activity counseling