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2014;4:e004376 Funding This study was funded by Enterprising Birmingham, University of Birmingham, UK, from 1st August 2016

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In particular, the animal study 7 in which pharmacological inhibition of GPx activity significantly reduced brain infarct damage suggested that under reduced oxygen supply, H 2 O 2 may exert either physiological or protective roles in the brain through its metabolic degradation to oxygen by catalase compensating for the lack of oxygen that occurs in the tissue after an ischemic event

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In HC, PET scans were performed on a Philips Ingenuity PET-MRI scanner and included two phases: a dynamic scan reconstructed into 18 frames with increasing durations, followed by four 5-minute static frames 26

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