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Only six cases of dihydrofolate reductase deficiency have been reported to date, three of which were homozygous mutations in the DHFR gene p.Asp153Val and three were attributed to p.Leu80Phe mutations [116, 117]

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Notably, polyunsaturated fatty acids (PUFAs), folates and probiotics have shown positive effects on these aspects (Table 2)

DAILY BEAUTY & WELLNESS SUPPORT: Healthy-looking skin starts with good nutrition

Researchers must justify TB-500 use under the 3Rs framework (replacement, reduction, refinement) and demonstrate that scientific objectives cannot be achieved through non-animal methods