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Up to now, various types of endogenous/exogenous stimulus-sensitive Pt prodrugs have been reported, such as pH-sensitive ( 2K ) via a ROS-liable thioketal spacer and assembled them with reduction-responsive heterodimer of photosensitizer pheophorbide A (PPa) and indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor (NLG919) (Figure 2A)

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