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Weight loss also typically increases sex hormone-binding globulin (SHBG) levels as insulin sensitivity improves, which affects the interpretation of total versus free testosterone measurements

c-reactive protein is a marker of inflammation and is not specific

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Excessive caffeine intake can lead to side effects like jitters, anxiety, and headache, as well as creating tolerance, reducing its potential benefits

It refers to evaluating whether GLP-1 receptor agonists could benefit individuals who have normal body weight but still show significant cardiometabolic risk factors such as insulin resistance, dyslipidemia, or cardiovascular disease

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