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When treatments were initiated, mice had ad libitum access to food, water, and kaolin pellets

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The 2023 international PCOS guideline confirms letrozole as first-line for ovulation induction, with metformin recommended for adults with PCOS and BMI 25 kg/m for metabolic and anthropometric outcomes

The medication's prolonged half-life of approximately five days allows for weekly dosing while maintaining therapeutic drug levels

( [Google Scholar] 4.Bjerre Knudsen L, Wichmann Madsen L, Andersen S, et al