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With time, disc bulges or herniations, malalignment of the vertebral segments (spondylolisthesis), osteophyte (bone spur) formation, enlargement (hypertrophy) of facet joints, and ligamentum flavum thickening may all gradually contribute to a narrowing of the spinal canal

The Main Factors Affecting Bioavailability Physicochemical properties of the drug, such as lipid solubility, water solubility, pKa value, molecular size and morphology, stability, etc ., which affect the drug's ability to dissolve in the gastrointestinal tract and penetrate biofilms

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