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FOLR1-Related Cerebral Folate Transport Deficiency

Furthermore, the more recent observational data suggesting that the combination of high folate and low vitamin B-12 is associated with the worsening of both clinical outcomes and elevations in functional biomarkers of vitamin B-12 (23, 40, 41) imply that depletion of holoTC is attained even without stimulating hematopoiesis

The 12-month animal safety data is encouraging but does not directly translate to human dosing

In fertility scenarios, supporting libido and performance anxiety can drive more frequent and optimally timed intercourse or assisted interventions as a complementary adjunct versus a core fertility player

Regular provider feedback on diagnostic performance can drive systematic improvements

Outcome data from two prospective studies