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The SLC52A2 gene is highly expressed in the brain and mutations in this gene result in the autosomal recessive progressive neurological disorder known as Brown-Vialetto-Van Laere syndrome 2

IGF-I administered to GH deficient rats (or to patients with GH receptor defects) normalizes the low GFR as does GH replacement in GH deficiency

FIGURE 6 Conclusion The essential requirement for sulfur uptake and incorporation into essential biomolecules by pathogenic fungi represents a potential therapeutic Achilles heel especially because many of the associated enzymatic reactions are fungalspecific

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