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Can also be taken orally for direct gut benefit

References 1.OBrien M

In men, vitamin D deficiency can lower testosterone levels, affecting sperm quality

7.7 Antiretroviral Drugs Loss of virological control has been reported in HIV-infected patients taking orlistat concomitantly with antiretroviral drugs such as atazanavir, ritonavir, tenofovir disoproxil fumarate, emtricitabine, and with the combinations lopinavir/ritonavir and emtricitabine/efavirenz/tenofovir disoproxil fumarate

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Mild side-effects like heartburn and indigestion are possible, and I usually keep the dose to around 2 grams a day