A C20 fatty di-acid moiety attached via a Glu2AEEA linker enables reversible serum albumin binding and extends the circulating half-life to approximately six days, supporting once-weekly research dosing protocols
A data-independent (DIA) acquisition method was used, in which one full scan (3001,650 m/z , maximum ion fill time of 45 ms, normalized AGC target 300%, R = 120.000 at 200 m/z ) was followed by 66 tMS2 fragment scans of unequally spaced windows with 1 Th overlap, covering the same m/z range (fill time 22 ms, normalized AGC target 1,000%, normalized high-collision density energy of 30%, R = 15.000)
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A key muscle in the lower esophagus, the LES is our bodys natural barrier to reflux
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