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287(3): 2368 Gerber G, Zhong J, Youn D, et al
Front Biosci-Landm
Molecular and Cellular Biology 24, 8477-8486CrossRefGoogle ScholarPubMed 23Kobayashi, A., Kang, M.I., Okawa, H
Recent evidence using several public datasets from The Cancer Genome Atlas (TCGA), Kyoyo Encyclopedia of Genes and Genomes (KEGG), AmiGO (2) and Reactome Pathways databases has identified two choline metabolism-related genes (choline kinase , CHKB , and phosphatidylethanolamine N-methyltransferase, PEMT ) as key genes involved in the pathogenesis of human colorectal cancer (220, 221)
Based on a comprehensive analysis of the literature, we propose that BACH1 is a typical context-dependent transcription factor, and its function is strongly regulated by the intracellular redox state: ROS levels and heme metabolism significantly influence the expression and activity of BACH1
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