ghk-cu plasma levels with age concentration decline Effects of on concentrations of cholecystokinin, glucagon-like peptide 1, and peptide YY and their relation to appetite and pyloric motility ghk-cu in human plasma – GHK-Cu Dosage: Protocols & Charts

This implies that the FOXO4-p53 interaction effectively induces cellular senescence

Instead GHK seems to have a more multi-faceted effect on many different systems

Copper is an important cofactor for enzymes involved in: Collagen cross-linking Antioxidant defense Wound repair Extracellular matrix remodeling GHK-Cu appears to support: Collagen synthesis Elastin production Glycosaminoglycan production Angiogenesis Antioxidant activity Matrix metalloproteinase regulation Why GHK-Cu is popular in aesthetics: GHK-Cu is commonly discussed in skin rejuvenation because it may support skin thickness, elasticity, firmness, wound repair, hair follicle signaling, reduced inflammation, and improved skin texture

[PubMed] [Google Scholar] 131.Peng J., Ma P., Wu X., et al

Orphan neuropeptides and receptors: Novel therapeutic targets

Most injection site reactions resolve within 24-48 hours