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Nitric oxide is a naturally produced reactive free radical that plays an important role in cell signaling and pressure regulation, but it can be produced in abundance, causing persistent infections, excessive inflammation, as well as the formation of highly destructive compounds such as peroxynitrite [13]

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This is Adverse Reactions section data from the prescribing information, applicable to the SELECT trial population specifically

SOD2 (Mitochondrial SOD) SOD2, also called manganese SOD (Mn-SOD), is located exclusively in the mitochondrial matrix

In the other direction, the presence of severe periodontitis has been shown to increase the risk of hyperglycaemia in people with diabetes and compromise glycaemic control in people without diabetes (Demmer et al, 2010

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