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DMF mediates NRF2-dependent and independent mechanisms on TSS pathway CBS activation DMF activates NRF2, the master regulator for the antioxidative stress response, to regulate the expression of proteins involved in iron hemostasis, and GSH synthesis such as HMOX1, NQO1, FTH, FTL, SLC40A1 in a variety of cellular systems 37

The role of kynurenine pathway and NAD(+) metabolism in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

The two are paired because they work on different scales : BPC-157 acts locally at the site of injury, while TB-500 works systemically across the whole body