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In renal tubular epithelial cells treated with calcium oxalate (CaOx) to induce kidney stone formation, CHAC1 expression increases alongside a decreased GSH level, reduced GPX4 activity, increased iron and MDA content and elevated ROS and lipid peroxidation
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So, does glutathione cause purging, or is it merely a coincidence
M., Wei, P
These findings underscore that GSH regulates ferroptosis not only through peroxide detoxification but also by coordinating iron trafficking and Fe-S cluster integrity, thereby coupling redox defense to core metabolic fitness
10.1212/WNL.0000000000003391 506 ZhangJ.LiuK.SunL.YangL.LiuX.ZhuY.et al
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