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The analysis only assessed the short-term risk

10.1152/physrev.1987.67.4.1185 39 RaschkeS.ElsenM.GassenhuberH.SommerfeldM.SchwahnU.BrockmannB.et al (2013)

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Supporting our cytochrome c assays, we confirmed no change in mitochondrial outer membrane permeabilization (MOMP) in cells surviving 5FU treatment (compared to the dimethyl sulfoxide group), and no increase in mitochondrial apoptotic priming based on BH3-profiling 15,16 induced by 5FU treatment (Extended Data Fig