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These findings establish Piezo2 as an essential mechanotransducer underlying peripheral proprioception (Woo et al., 2015)

The authors analyzed data from 11 randomized controlled trials involving 2,466 participants (1,573 in the treatment group and 893 in the control group), all of which reported weight data both during and after treatment

For quantitative western blots, anti-rabbit immunoglobulin G (IgG) (H + L) (Dylight 800 conjugates) and anti-mouse IgG (H + L) (Dylight 680 conjugates) (Cell signaling) were used as secondary antibodies

Indeed, generating a fusion or conjugation between a peptide and a carrier molecule such as an antibody Fc fragment 23,24 or a full antibody 25,26 is a well described half-life extension strategy to address their rapid clearance from circulation and improve their therapeutic potential