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Mitochondrial mitophagy and apoptosis Mitophagy is a selective autophagic process critical for mitochondrial quality control, removing damaged mitochondria to prevent excessive ROS production and cytochrome c-mediated apoptosis

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Coupled to an increased uptake of glycine, serine and branched chain amino acids (leucine, isoleucine and valine), which are required for protein synthesis, this generates sufficient building blocks (nucleic acids, proteins and membranes) for proliferation

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