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Exenatide formulations show variable nausea rates: the twice-daily immediate-release preparation (Byetta) tends to produce higher rates of nausea (approximately 3050%), whilst the once-weekly extended-release formulation (Bydureon) demonstrates improved tolerability with nausea rates of approximately 1424%, according to their respective SmPCs

Vishvkarma R et al

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Yes they knew of the rum, no they had not heard any reports of anything such as I described, and no there was nothing particularly unusual about the production methods employed by Kikusui Shuzo distillery on Honshu, using Shikoku sugar cane which they process on a column still and age for three years

Common gastrointestinal side effects include nausea, constipation, diarrhoea and abdominal discomfort, typically mild and transient

Alpha-lipoic Acid: An Antioxidant with Anti-Aging Properties for Disease Therapy