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These mechanisms contribute to its inclusion in experimental models of neuroprotection, metabolic longevity, and regenerative aging research

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Small molecules such as RSL3 and erastin, which primarily target GPX4 and SLC7A11, respectively, demonstrate that impairment of cystine uptake or lipid peroxide detoxification is sufficient to directly trigger ferroptotic cell death

de Ferranti S, Mozaffarian D

10.2337/db19-1176 185 ZeccaL.YoudimM

Julie Colvin