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Insulin resistance constitutes an important mechanistic link between prolactin abnormalities and obesity-related metabolic disorders, and is a core pathological feature of metabolic syndrome and type 2 diabetes ( A hyperglycemic clamp test showed that individuals with higher circulating prolactin levels had significantly reduced insulin sensitivity ( 4.4 Hypothalamicpituitarygonadal axis disruption The HPG axis is extremely sensitive to circulating prolactin levels

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Our previous studies have illustrated that VRK2 is an oncogenic driver of malignant growth of PC, and its overexpression is positively correlated with poor outcome of PC [17]

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TABLE 8 TMA value in blood of C57Bl/6-Fmo3 em1smoc mice