Though the biological relevance of CIRTs is still largely unknown, their abundance in neuronal dendrites (and also in enucleated platelets) suggest that endogenous cytoplasmic transcripts harboring retained intronic substrates could be subject to extranuclear splicing, thereby obviating the need for shuttling molecules to and from the nucleus for processing (Buckley et al., In this order of ideas, it is tempting to speculate that CIRT in Gpx4-I gene may be part of the normal endogenous post-transcriptional regulation pathway
Optional research biomarkers: senescence markers (p16^INK4a, SA--gal), SASP cytokine profile (IL-6, IL-1, MMPs) if lab resources permit
24 A strong association between these psychological issues and body image distress has been shown
BPC-157 nasal spray: mechanisms and research Understanding how BPC-157 works provides context for evaluating nasal delivery
10.1016/j.bbamem.2008.03.007 27 DimovaR
In nasal sprays, copper is proposed to improve breathing during colds, rhinitis, or sinusitis
